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leaf 科學驗證

從機制到臨床
累積 TWK10科學實證

研究橫跨營養、代謝、運動、肌肉與熟齡健康，從機制探索逐步走向人體臨床驗證。

超過 400 位受試者驗證，多國大型臨床實驗支持，多國專利認證
TWK10

以國際期刊發表累積科學證據

運動表現

  1. Chen, Y.-M., Wei, L., Chiu, Y.-S., Hsu, Y.-J., Tsai, T.-Y., Wang, M.-F., & Huang, C.-C. (2016). Lactobacillus plantarum TWK10 supplementation improves exercise performance and increases muscle mass in mice. Nutrients, 8(4), 205. https://doi.org/10.3390/nu8040205 【動物】

    補充 TWK10 可增加小鼠肌肉量與運動耐力，並降低疲勞指標。

  2. Huang, W.-C., Hsu, Y.-J., Li, H., Kan, N.-W., Chen, Y.-M., Lin, J.-S., Hsu, T.-K., Tsai, T.-Y., Chiu, Y.-S., & Huang, C.-C. (2018). Effect of Lactobacillus plantarum TWK10 on improving endurance performance in humans. Chinese Journal of Physiology, 61(3), 163–170. https://doi.org/10.4077/CJP.2018.BAH587 【人體】

    補充 TWK10 連續 6 週，可提升約 27% 運動耐力，幫助體能更持久。

  3. Huang, W.-C., Lee, M.-C., Lee, C.-C., Ng, K.-S., Hsu, Y.-J., Tsai, T.-Y., Young, S.-L., Lin, J.-S., & Huang, C.-C. (2019). Effect of Lactobacillus plantarum TWK10 on exercise physiological adaptation, performance, and body composition in healthy humans. Nutrients, 11(11), 2836. https://doi.org/10.3390/nu11112836 【人體】

    補充 TWK10 可提升運動耐力、增加肌肉量，同時改善體脂表現。

  4. Huang, W.-C., Chen, Y.-H., Chuang, H.-L., Chiu, C.-C., & Huang, C.-C. (2019). Investigation of the effects of microbiota on exercise physiological adaption, performance, and energy utilization using a gnotobiotic animal model. Frontiers in Microbiology, 10, 1906. https://doi.org/10.3389/fmicb.2019.01906 【動物】

    TWK10 可調節能量利用與基礎代謝，支持更有效率的能量運用。

  5. Chen, Y.-M., Liao, C.-C., Huang, Y.-C., Chen, M.-Y., Huang, C.-C., Chen, W.-C., & Chiu, Y.-S. (2020). Proteome and microbiota analysis highlight Lactobacillus plantarum TWK10 supplementation improves energy metabolism and exercise performance in mice. Food Science & Nutrition, 8(7), 3525–3534. https://doi.org/10.1002/fsn3.1635 【動物／機制】

    TWK10 可促進脂肪與能量利用，進一步支持運動表現。

  6. Lee, C.-C., Liao, Y.-C., Lee, M.-C., Cheng, Y.-C., Chiou, S.-Y., Lin, J.-S., Huang, C.-C., & Watanabe, K. (2022). Different impacts of heat-killed and viable Lactiplantibacillus plantarum TWK10 on exercise performance, fatigue, body composition, and gut microbiota in humans. Microorganisms, 10(11), 2181. https://doi.org/10.3390/microorganisms10112181 【人體】

    TWK10 益生菌與後生元兩種型態，皆可提升運動耐力，並改善疲勞表現。

  7. Cheng, Y.-C., Lee, C.-C., Lee, M.-C., Hsu, H.-Y., Lin, J.-S., Huang, C.-C., & Watanabe, K. (2023). Effects of heat-killed Lactiplantibacillus plantarum TWK10 on exercise performance, fatigue, and muscle growth in healthy male adults. Physiological Reports, 11, e15835. https://doi.org/10.14814/phy2.15835 【人體】

    補充 TWK10 後生元連續 6 週，可提升握力、肌肉量與運動耐力。

  8. Liao, J.-F., Lee, C.-C., Lee, M.-C., Hsu, H.-Y., Wang, M.-F., Huang, C.-C., et al. (2025). A comprehensive approach, based on the use of Caenorhabditis elegans, mouse, and human models, elucidates the impact of Lactiplantibacillus plantarum TWK10 on exercise performance and longevity. Current Research in Food Science, 10, 101015. https://doi.org/10.1016/j.crfs.2025.101015 【跨物種／人體】

    TWK10 從線蟲、小鼠到人體皆展現體能與打造健康身體組成效益。

促蛋白吸收

  1. Lee, M.-C., Chiu, C.-H., Liao, Y.-C., Cheng, Y.-C., Lee, C.-C., Ho, C.-S., et al. (2024). Gut microbiota modulation and amino acid absorption by Lactiplantibacillus plantarum TWK10 in pea protein ingestion: TWK10 boosts gut microbiota, amino acid uptake. Current Research in Food Science, 9, 100917. https://doi.org/10.1016/j.crfs.2024.100917 【人體】

    搭配豌豆蛋白補充 TWK10，可提升總胺基酸 2 倍以上，讓蛋白營養更有效被身體利用。

熟齡健康

  1. Lee, C.-C., Liao, Y.-C., Lee, M.-C., Lin, K.-J., Hsu, H.-Y., Chiou, S.-Y., Young, S.-L., Lin, J.-S., Huang, C.-C., & Watanabe, K. (2021). Lactobacillus plantarum TWK10 attenuates aging-associated muscle weakness, bone loss, and cognitive impairment by modulating the gut microbiome in mice. Frontiers in Nutrition, 8, 708096. https://doi.org/10.3389/fnut.2021.708096 【動物】

    補充 TWK10 可減緩老化造成的肌力與骨質流失，並維持認知表現。

  2. Lee, M.-C., Tu, Y.-T., Lee, C.-C., Tsai, S.-C., Hsu, H.-Y., Tsai, T.-Y., Liu, T.-H., Young, S.-L., Lin, J.-S., & Huang, C.-C. (2021). Lactobacillus plantarum TWK10 improves muscle mass and functional performance in frail older adults: A randomized, double-blind clinical trial. Microorganisms, 9(7), 1466. https://doi.org/10.3390/microorganisms9071466 【人體】

    熟齡者補充 TWK10，可提升下肢肌力約 51%，並改善行動敏捷度。

  3. Xing, G., et al. (2024). Lactiplantibacillus plantarum TWK10 含有食品の摂取が日本の健常な中高年男女の筋肉および体脂肪に及ぼす影響―ランダム化プラセボ対照二重盲検並行群間比較試験―. 薬理と治療, 52(7), 833–846. 【人體】

    中高齡族群補充 TWK10，有助維持肌肉量與去脂體重，並改善體脂。

代謝健康

  1. Zheng, Y., et al. (2024). Evaluate and compare the anti-obesity effects of two probiotic preparations in high-fat diet-induced obese mice. Journal of Functional Foods, 106199. 【動物】

    補充 TWK10 可減少高脂飲食造成的體重與脂肪累積。

  2. Chen, Y.-C., Wang, H.-Y., Ogita, F., Hung, C.-H., Kuo, C.-H., Wang, J.-P., Wang, C.-M., Hou, C.-W., & Wang, T.-Y. (2024). Effects of probiotic supplementation with high-intensity interval training on cardiorespiratory endurance and metabolism in middle-aged obese women. Journal of the International Society of Sports Nutrition, 21(1), 2425609. https://doi.org/10.1080/15502783.2024.2425609 【人體】

    TWK10 搭配 HIIT，可進一步支持心肺耐力與健康體態。

  3. Liu, T.-H., et al. (2025). Lactobacillus plantarum TWK10 relieves loperamide-induced constipation in rats fed a high-fat diet via modulating enteric neurotransmitters, short-chain fatty acids and gut microbiota. Food & Function. 【動物】

    補充 TWK10 可改善腸道排空與排便功能，並調節腸道菌相。

機能探索

  1. Cheng, C.-P., Tsai, S.-W., Chiu, C.-P., Pan, T.-M., & Tsai, T.-Y. (2013). The effect of probiotic-fermented soy milk on enhancing the NO-mediated vascular relaxation factors. Journal of the Science of Food and Agriculture, 93(5), 1219–1225. 【細胞／血管】

    TWK10 發酵豆乳可促進血管舒張相關作用，支持血管健康。

  2. Chang, C.-J., Dai, R.-Y., Leu, Y.-L., & Tsai, T.-Y. (2015). Effects of the melanogenic inhibitor, uracil, derived from Lactobacillus plantarum TWK10-fermented soy milk on anti-melanogenesis in B16F0 mouse melanoma cells. Journal of Functional Foods, 17, 314–327. 【細胞】

    TWK10 發酵豆乳活性成分可抑制黑色素生成，展現亮白潛力。

  3. Liu, T.-H., Chiou, J., & Tsai, T.-Y. (2016). Effects of Lactobacillus plantarum TWK10-fermented soymilk on deoxycorticosterone acetate-salt-induced hypertension and associated dementia in rats. Nutrients, 8(5), 260. https://doi.org/10.3390/nu8050260 【動物】

    TWK10 發酵豆乳可改善高血壓與認知表現，支持血管與腦部健康。

  4. Chuang, Y.-C., Cheng, M.-C., Lee, C.-C., Chiou, T.-Y., & Tsai, T.-Y. (2019). Effect of ethanol extract from Lactobacillus plantarum TWK10-fermented soymilk on wound healing in streptozotocin-induced diabetic rat. AMB Express, 9(1), 163. https://doi.org/10.1186/s13568-019-0886-2 【細胞／動物】

    TWK10 發酵豆乳萃取物可降低發炎反應，並促進傷口修復。

  5. Liu, T.-H., Lin, W.-J., Cheng, M.-C., & Tsai, T.-Y. (2020). Lactobacillus plantarum TWK10-fermented soymilk improves cognitive function in type 2 diabetic rats. Journal of the Science of Food and Agriculture, 100(14), 5152–5161. https://doi.org/10.1002/jsfa.10564 【動物】

    TWK10 發酵豆乳可改善糖尿病動物的學習與記憶表現。

  6. Liu, T.-H., Chiang, W.-T., Cheng, M.-C., & Tsai, T.-Y. (2022). Effects of germination black soy milk fermented with Lactobacillus plantarum TWK10 on anti-oxidative and anti-melanogenesis. Applied Sciences, 12(1), 277. https://doi.org/10.3390/app12010277 【細胞／斑馬魚】

    TWK10 發酵黑豆乳可提升抗氧化能力，並減少黑色素生成。

  7. Liu, T.-H., Lin, W.-J., Cheng, M.-C., & Tsai, T.-Y. (2024). Exploration of the anti-photoaging mechanisms of Lactiplantibacillus plantarum TWK10 in a UVB-induced mouse model. Applied Sciences, 14(20), 9497. 【動物】

    補充 TWK10 可改善 UVB 引起的皺紋與水分流失，維持肌膚狀態。

  8. Liu, T.-H., Hsu, Y.-H., Hsiao, R.-Y., Cheng, M.-C., Leu, Y.-L., & Tsai, T.-Y. (2025). Improved mechanism of the bioactive compounds isolated from Lactobacillus plantarum TWK10-fermented soymilk in periodontal disease. Food & Function, 16(4), 1517–1533. https://doi.org/10.1039/D4FO04049J 【細胞／抗菌】

    TWK10 發酵豆乳活性成分可抑制牙周致病菌與生物膜形成。

生殖健康

  1. Liu, C.-Y., Chen, Y.-W., Tsai, T.-Y., Liu, T.-H., Chang, T.-C., & Tsao, C.-W. (2024). Lactiplantibacillus plantarum 1008 enhances testicular function and spermatogenesis via the modulation of gut microbiota in male mice with high-fat-diet-induced obesity. Biology, 13(11), 890. https://doi.org/10.3390/biology13110890 【動物】

    補充 TWK10 可改善肥胖雄鼠的精子品質與睪丸功能。

  2. Liu, C.-Y., Tsai, T.-Y., Liu, T.-H., Chang, T.-C., Chen, Y.-W., & Tsao, C.-W. (2024). Lactiplantibacillus plantarum 1008 promotes reproductive function and cognitive activity in aged male mice with high-fat-diet-induced obesity by altering metabolic parameters and alleviating testicular oxidative damage, inflammation and apoptosis. Antioxidants, 13(12), 1498. https://doi.org/10.3390/antiox13121498 【動物】

    補充 TWK10 可改善老齡肥胖雄鼠的生殖功能與認知表現。

安全驗證

  1. Hsu, H.-Y., et al. (2022). Safety assessment of Lactiplantibacillus plantarum TWK10 based on whole-genome sequencing, phenotypic, and oral toxicity analysis. Microorganisms, 10(4), 784. https://doi.org/10.3390/microorganisms10040784 【安全／動物／基因】

    從基因體、抗生素敏感性到口服毒理，完整驗證 TWK10 菌株安全性。

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